Osteomyelitis

Osteomyelitis

Bottom Line

Treatment often requires both debridement and antibiotic therapy.
Antibiotic therapy should be tailored based upon biopsy when available.
Empiric coverage of MRSA is not required unless the patient has previous MRSA infection or MRSA colonization.

Empiric Therapy

Empiric therapy based on mechanism of action

Hematogenous (monomicrobial): Cefazolin or Cloxacillin
Contiguous (polymicrobial or monomicrobial):

Open fracture or orthopedic surgery (S. aureus and Coagulase negative Staphlycoccus): Vancomycin
Diabetic foot infection: Cefazolin + Fluoroquinolone

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