Osteomyelitis

Empiric Therapy

 

Empiric therapy based on mechanism of action

  • Hematogenous (monomicrobial):    Cefazolin or  Cloxacillin
  • Contiguous  (polymicrobial or monomicrobial):

  • Open fracture or orthopedic surgery (S. aureus and Coagulase negative Staphlycoccus):    Vancomycin
  • Diabetic foot infection:     Cefazolin  + Fluoroquinolone