Endocarditis

Bottom Line

 

  • Empiric MRSA coverage is required in: injection drug use, sepsis, previous history of MRSA infection or MRSA colonization .
  • The addition of gentamicin has been shown to be beneficial in Enterococcal and right sided S. aureus NV endocarditis.
  • The addition of rifampin is beneficial in S. aureus PV endocarditis.  
  • Antibiotic therapy should be tailored to blood culture results.  
  • If MSSA is cultured, then cefazolin or cloxacillin is the treatment of choice

Empiric Therapy