Endocarditis
Endocarditis
Bottom Line
- Empiric MRSA coverage is required in: injection drug use, sepsis, previous history of MRSA infection or MRSA colonization .
- The addition of gentamicin has been shown to be beneficial in Enterococcal and right sided S. aureus NV endocarditis.
- The addition of rifampin is beneficial in S. aureus PV endocarditis.
- Antibiotic therapy should be tailored to blood culture results.
- If MSSA is cultured, then cefazolin or cloxacillin is the treatment of choice
Empiric Therapy
Native valve (NV): vancomycin + gentamicin
- Prosthetic valve (PV): vancomycin + gentamicin +/- rifampin