Febrile Neutropenia
Febrile Neutropenia
Anticipated duration of
neutropenia of ≥ 7 days
AND
Profound neutropenia – ANC ≤ 0.1 x109/L
AND
Profound neutropenia – ANC ≤ 0.1 x109/L
- ANC count is the neutrophil count, NOT the total white count (WBC)
- Blood cultures must be drawn peripherally and from any central venous catheter (CVC)
- Empiric coverage for those with indwelling CVCs can include vancomycin, if signs or symptoms suggest a line-associated infection
- Empiric Treatment must include antipseudomonal coverage
Empiric Therapy
Without CVC
- Ceftazidime 2g IV q8h or Piperacillin /Tazobactam 4.5g IV q6h (adjust for renal dysfunction if present)
- Any of the above PLUS Vancomycin at 15mg/kg IV q12h (adjust for renal dysfunction if present)