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Clinical Condition
Meningitis
Respiratory
Endocarditis
Intra-abdominal
Urinary Tract Infection
Skin and Soft tissue
Skeletal (Bone & Joints)
Bacteremia and Undifferentiated
Microbiology
Gram positive cocci
Gram negative bacilli
Antibiotics
Penicillin
Ampicillin
Oxacillin
Cefazolin
Cefuroxime
Ceftriaxone
Ceftazidime
Imipenem
Meropenem
Piperacillin-Tazobactam
Ticarcillin-Clavulanic acid
Trimethroprim/Sulfamethoxazole
Ciprofloxacin
Levofloxacin
Gentamicin
High Level Gentamicin
High Level Streptomycin
Tobramycin
Tetracycline
Erythromycin
Clindamycin
Nitrofurantoin
Location
Complicated Upper tract
Complicated Upper Tract
Complicated UTI's are classified as patients who are male, with structural disease, immunosuppressed, with a renal or perinephric abscess or prostatitis.
Bottom Line
Treatment of pyelonephritis is 7 days if a fluoroquinolone (FQ) is used and 14 days with any other antibiotic.
Treatment can be changed from IV to PO when afebrile x 48h
The treatment of a renal abscess is drainage.
Empiric Therapy
Pyelonephritis (inpatient)
Ceftriaxone
1g IV Daily x 14d OR
Ciprofloxacin
400MG IV BID (or 500MG PO BID) x 7 days
Renal abscess
Drainage and antibiotics as per pyelonephritis (inpatient) treatment.
Prostatitis
Acute
TMP/SMX
160/800 MG (1 DS tab) PO BID x 14-28 d OR
Fluoroquinolone x 14-28d
Chronic
TMP/SMX
160/800 MG (1 DS tab) PO BID x 6-12 weeks OR
Fluoroquinolone x 6-12 weeks
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