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Clinical Condition
Meningitis
Respiratory
Endocarditis
Intra-abdominal
Urinary Tract Infection
Skin and Soft tissue
Skeletal (Bone & Joints)
Bacteremia and Undifferentiated
Microbiology
Gram positive cocci
Gram negative bacilli
Antibiotics
Penicillin
Ampicillin
Oxacillin
Cefazolin
Cefuroxime
Ceftriaxone
Ceftazidime
Imipenem
Meropenem
Piperacillin-Tazobactam
Ticarcillin-Clavulanic acid
Trimethroprim/Sulfamethoxazole
Ciprofloxacin
Levofloxacin
Gentamicin
High Level Gentamicin
High Level Streptomycin
Tobramycin
Tetracycline
Erythromycin
Clindamycin
Nitrofurantoin
Location
Bacteremia Line Related
Bacteremia Line Related
Bottom Line
Catheter management
(removal, exchange, salvage) and antibiotic therapy are required
Coagulase negative staphylococci are the most common organisms found in catheter related blood stream infections
In general, systemic antibiotic therapy is NOT necessary in the following circumstances:
Positive catheter tip culture in the absence of clinical signs of infection
Positive blood cultures obtained through a catheter with negative cultures through a peripheral vein.
Phlebitis in the absence of infection
Empiric Therapy
Vancomycin
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